Grilled Cheese, Avocado & Pepperoni Panini
Meat + Grilling Out

Grilled Cheese, Avocado & Pepperoni Panini Recipe

Grilled Cheese, Avocado & Pepperoni Panini

Grilled Cheese, Avocado & Pepperoni Panini

Grilled Cheese, Avocado & Pepperoni Panini

This recipe has become an all time favorite around our home. It's comfort food with a twist, think the cool Italian cousin of the Grilled Cheese Sandwich. Yes, it's a Grilled Cheese Panini!

Making this Grilled Cheese, Avocado & Pepperoni Panini at home it's super easy, even easier than making a grilled cheese sandwich!

So this is perfect for crazy busy weekdays when you just don't feel (or don't have the time) to cook an elaborated dinner but still want something filling, delicious and that everyone loves.

The first part of the Grilled Cheese, Avocado & Pepperoni Panini: The bread. For this recipe, the best bread is a crusty one. While it's also delicious with traditional sandwich bread or with slices of a huge loaf, in my experience the best result is with crusty bread. I usually buy a lot of it at the supermarket bakery and then I freeze it. Freezing bread is super easy and it allows you to store it for 6 to 8 months, so it's definitely something worth to stock up.

Grilled Cheese, Avocado & Pepperoni Panini

After you have your bread open it's time to fill it. The most important ingredient is the cheddar cheese, then I add some mashed avocado to make it creamier, some pepperoni slices and a thick tomato slice. I close the sandwich and drizzle the top with just a bit of oil. I like to use olive oil but any oil you have on hand works out.

Grilled Cheese, Avocado & Pepperoni PaniniThen comes the cooking part, you can grill it just like you would with a grilled cheese sandwich or you can speed things up and make it in the oven. I just place all the sandwiches into a baking pan and take it to the oven for 15 minutes. Making it in the over is so much faster and it's hand off cooking (my favorite kind of cooking!).

Once your Grilled Cheese, Avocado & Pepperoni Panini is done you can cut it in half so it looks like the panini they serve in restaurants and serve it as is or with some potato chips.

Grilled Cheese, Avocado & Pepperoni Panini

Grilled Cheese, Avocado & Pepperoni Panini


  • 1 loaf of crusty bread
  • ½ mashed avocado
  • 6-8 Pepperoni slices
  • ½ tomato, thickly sliced
  • 2 Sliced cheddar cheese
  • extra virgin olive oil


  1. Cut in half the loaf bread. Layer the mashed avocado, pepperoni, tomato and cheddar cheese.
  2. Close your sandwich and drizzle with olive oil.
  3. Place into a baking pan and take to the oven.
  4. Bake for 10 minutes or until golden brown.
  5. Serve and enjoy.

Grilled Cheese, Avocado & Pepperoni Panini

What's your favorite sandwich?


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20 Comments Leave a Comment »

  1. Cheryl

    I’ve never had avocado on a sandwich. Looks so good!

  2. Kristen

    I’m pretty sure my family would love this!

  3. Robin Masshole Mommy

    What an awesome flavor combination. This sounds soooo good.

  4. Pam

    This looks so good! I am obsessed with avocado, I could eat it on everything.

  5. I really love a grilled chicken panini, but now this is going on my fave list, too. That looks exceptional.

  6. Maureen

    This looks like a yummy panini option, I want to make it and eat it right up, it’s making my stomach growl!

  7. This sounds really good. I have really gotten into putting avocado in a lot of recipes lately. It’s so good for you.

  8. I’m liking this combination! I may have to try this for a solo lunch sometime this week.

  9. I’m always looking for great recipes that include avocados. My fave! And it’s so good for you too. Thanks for sharing this looks great

  10. Yes! I need this in my belly right now. My favorite sandwich would definitely include avocado.

  11. Valerie Gray

    I love a good grilled cheese. I never though about adding avocado or pepperoni to them. Now I’m hungry!

  12. My twins are obsessed with pepperoni! I never thought of putting it on a sandwich! I need to make this panini for them!

  13. nicole escat

    wow i love it! i will try it tomorrow at home
    i am a cheese and pepperoni lover

  14. I wouldn’t have thought of this flavor combination. But it looks delicious!

  15. I love paninis and am always looking for new ways to make them. I’ve never thought of adding avocado. What a delicious sounding idea!

  16. I love that you updated a childhood fave sandwich! This adult version looks so much tastier than the child version 🙂

  17. Looks yummy. This would also be to adapt to an appetizer. You could do it on a cracker instead of bread. YUM!

  18. Michele P

    This looks yummy! I love paninis, one of my faves is the Frontega Chicken panini at Panera, so good!

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